Ginger Benefits Those With Liver Disease Ginger For Eye Health

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Written by Greg Arnold, DC, CSCS. Of the 44 study participants, those who took 2 grams of ginger daily for 12 weeks had significant improvements in inflammatory proteins, liver enzymes, insulin resistance, and overall health compared to the control group.

Nonalcoholic fatty liver disease is one of the most common chronic liver diseases worldwide and occurs predominantly in obese, sedentary people and patients with type II diabetes ¹. It is usually associated with metabolic disorders such as obesity, insulin resistance ², hypertension, dyslipidemia and impaired fat me­tabolism ³, and it can increase mortality risk due to the associated cardiovascular disease ⁴.

There is currently no effective therapy for nonalcoholic fatty liver disease other than lifestyle modification ⁵ that focuses on blood sugar control and minimizing cell damage ^6,7. Alternative therapies in the form of cinnamon supplementation ⁸ and vitamin E combined with phosphatidylcholine ⁹ may benefit those with nonalcoholic fatty liver disease.

The study involved 44 patients (20 males, 24 females) aged 44 to 47 with nonalcoholic fatty liver disease. They were assigned to take either 2 grams of ginger (23 patients) or a placebo (21 patients) per day for 12 weeks. They were also given advice on modifying their diet and a physical activity program based on the National Institutes for Health and the North American Association for the Study of Obesity ¹⁰. Blood samples were taken before and after the study to measure for liver health.

After 12 weeks, the following benefits were seen on inflammatory proteins (hs-CRP, TNF-alpha), liver enzyme health (ALT, GGT), insulin sensitivity (HOMA-IR), and overall liver health (steatosis score):

	Ginger	Placebo	p - value
ALT (Units/Liter)	16.7% decrease (36.59 to 30.5)	10.8% decrease (34.53 to 30.82)	0.045
GGT (Units/Liter)	25% decrease (40.32 to 30.26)	6% decrease (44.45 to 41.82)	0.001
HOMA-IR	25.3% decrease (2.93 to 2.19)	11.6% decrease (2.69 to 2.38)	0.022
Steatosis score	17% decrease (307.81 to 255.77)	3.9% decrease (287.45 to 276.36)
hs-CRP (nanograms/milliliter)	26% decrease (4.62 to 3.42)	7.4% decrease (4.79 to 4.44)	0.016
TNF-alpha (picograms/mL)	24.8% decrease (4.68 to 3.52)	5% decrease (3.03 to 2.88)	0.01

For the researchers, “ginger supplementation could increase the effectiveness of lifestyle interventions (diet modification and physical activity) compared with life­style interventions alone for treatment of nonalcoholic fatty liver disease” but that “wheth­er these effects will be sustained and/or augmented with longer treatment durations remains to be determined.”

Source: Eslamparast T., Poustchi H., Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr 2014;99:535–42.

© 2014 American Society for Nutrition

Posted August 3, 2016. 

Greg Arnold is a Chiropractic Physician practicing in Hauppauge, NY.  You can contact Dr. Arnold directly by emailing him at 

References:

1. Ong JP, Younossi ZM. Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis. 2007;11(1):1-16, vii.
2. Ratziu V, Giral P, Charlotte F, et al. Liver fibrosis in overweight patients. Gastroenterology. 2000;118(6):1117-1123.
3. Musso G, Gambino R, Cassader M, Pagano G. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med. 2011;43(8):617-649.
4. Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol. 2012;56(1):255-266.
5. Loria P, Adinolfi LE, Bellentani S, et al. Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease. A decalogue from the Italian Association for the Study of the Liver (AISF) Expert Committee. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2010;42(4):272-282.
6. Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. The New England journal of medicine. 2010;362(18):1675-1685.
7. Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology. 2010;52(1):79-104.
8. Askari F, Rashidkhani B, Hekmatdoost A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutrition research. 2014;34(2):143-148.
9. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free radical biology & medicine. 2012;52(9):1658-1665.
10. NHLBI. The Practical Guide Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. In:2000.

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