Breaking COVID-19's 'clutch' To Stop Its Spread: Researchers Engineer RNA-targeting Compounds That Disable The Pandemic Coronavirus' Replication Engine How To Prevent Covid 19 Disease
Allow, meet again, this time will explain about how to prevent covid 19 disease Breaking COVID-19's 'clutch' to stop its spread: Researchers engineer RNA-targeting compounds that disable the pandemic coronavirus' replication engine see in full
Scripps Research chemist Matthew Disney, PhD, and colleagues have created drug-like compounds that, in human cell studies, bind and destroy the pandemic coronavirus' so-called "frameshifting element" to stop the virus from replicating. The frameshifter is a clutch-like device the virus needs to generate new copies of itself after infecting cells. "Our concept was to develop lead medicines capable of breaking COVID-19's clutch," Disney says. "It doesn't allow the shifting of gears." Viruses spread by entering cells and then using the cells' protein-building machinery to churn out new infectious copies. Their genetic material must be compact and efficient to make it into the cells....